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Title | Design and Synthesis of a Highly Selective andIn Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 9070-9092, Year 2020 |
Publish date | May 30, 2020 (structure data deposition date) |
![]() | Preston, A. / Atkinson, S. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Jones, E.J. / Lindon, M. ...Preston, A. / Atkinson, S. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Gordon, L. / Grandi, P. / Gray, J.R.J. / Jones, E.J. / Lindon, M. / Michon, A.M. / Mitchell, D.J. / Prinjha, R.K. / Rianjongdee, F. / Rioja, I. / Seal, J. / Taylor, S. / Wall, I. / Watson, R.J. / Woolven, J. / Demont, E.H. |
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Methods | X-ray diffraction |
Resolution | 1.59 - 1.605 Å |
Structure data | ![]() PDB-6z7f: ![]() PDB-6z7g: |
Chemicals | ![]() ChemComp-PEG: ![]() ChemComp-EDO: ![]() ChemComp-QB5: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD2 / BROMODOMAIN CONTAINING PROTEIN 2 / ANTAGONIST / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 |