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-Structure paper
Title | GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 9045-9069, Year 2020 |
Publish date | May 31, 2020 (structure data deposition date) |
Authors | Watson, R.J. / Bamborough, P. / Barnett, H. / Chung, C.W. / Davis, R. / Gordon, L. / Grandi, P. / Petretich, M. / Phillipou, A. / Prinjha, R.K. ...Watson, R.J. / Bamborough, P. / Barnett, H. / Chung, C.W. / Davis, R. / Gordon, L. / Grandi, P. / Petretich, M. / Phillipou, A. / Prinjha, R.K. / Rioja, I. / Soden, P. / Werner, T. / Demont, E.H. |
External links | J. Med. Chem. / PubMed:32691589 |
Methods | X-ray diffraction |
Resolution | 1.26 - 1.624 Å |
Structure data | PDB-6z7l: PDB-6z7m: |
Chemicals | ChemComp-QAN: ChemComp-HOH: ChemComp-QAZ: |
Source |
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Keywords | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 / ANTAGONIST |