Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Structural Basis of AZD9291 Selectivity for EGFR T790M.
Journal, issue, pages	J. Med. Chem., Vol. 63, Page 8502-8511, Year 2020
Publish date	Apr 21, 2019 (structure data deposition date)
Authors	Yan, X.E. / Ayaz, P. / Zhu, S.J. / Zhao, P. / Liang, L. / Zhang, C.H. / Wu, Y.C. / Li, J.L. / Choi, H.G. / Huang, X. ...Yan, X.E. / Ayaz, P. / Zhu, S.J. / Zhao, P. / Liang, L. / Zhang, C.H. / Wu, Y.C. / Li, J.L. / Choi, H.G. / Huang, X. / Shan, Y. / Shaw, D.E. / Yun, C.H.
External links	J. Med. Chem. / PubMed:32672461
Methods	X-ray diffraction
Resolution	2.307 - 2.551 Å
Structure data	PDB-6jwl: Crystal structure of EGFR 696-1022 L858R in complex with AZD9291 Method: X-RAY DIFFRACTION / Resolution: 2.551 Å PDB-6jx0: Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization Method: X-RAY DIFFRACTION / Resolution: 2.53 Å PDB-6jx4: Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking Method: X-RAY DIFFRACTION / Resolution: 2.531 Å PDB-6jxt: Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization Method: X-RAY DIFFRACTION / Resolution: 2.307 Å
Chemicals	ChemComp-YY3: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide / medication, inhibitorYM ChemComp-HOH: WATER ChemComp-CL*: Unknown entry
Source	homo sapiens (human)
Keywords	TRANSFERASE / Complex / Inhibitor / EGFR. / ONCOPROTEIN / EGFR