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-Structure paper
Title | Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. |
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Journal, issue, pages | Febs J., Vol. 288, Page 1599-1613, Year 2021 |
Publish date | Jan 16, 2020 (structure data deposition date) |
Authors | Unni, S. / Deshmukh, P. / Krishnappa, G. / Kommu, P. / Padmanabhan, B. |
External links | Febs J. / PubMed:32672401 |
Methods | X-ray diffraction |
Resolution | 1.54 - 1.95 Å |
Structure data | PDB-6lrz: PDB-7c5e: PDB-7c60: |
Chemicals | ChemComp-EOU: ChemComp-ACT: ChemComp-PG5: ChemComp-SO4: ChemComp-HOH: ChemComp-FUM: ChemComp-PGE: ChemComp-NF3: |
Source |
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Keywords | CYTOSOLIC PROTEIN / beta-propeller domain / oxidative stress / Keap1-Nrf2 system / DMF / inhibitor complex |