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-Structure paper
Title | Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting alpha-Helix Backbone Oxygen by Halogen Bonding. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 8485-8494, Year 2020 |
Publish date | Oct 28, 2019 (structure data deposition date) |
![]() | Hsieh, C.M. / Chen, C.Y. / Chern, J.W. / Chan, N.L. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.92 Å |
Structure data | ![]() PDB-6l6e: |
Chemicals | ![]() ChemComp-E6L: ![]() ChemComp-ZN: ![]() ChemComp-MG: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase isoform 5 / avanafil / enzyme-drug complex / co-crystallization / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |