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TitleAntibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice.
Journal, issue, pagesNat Med, Vol. 26, Page 1264-1270, Year 2020
Publish dateApr 21, 2020 (structure data deposition date)
AuthorsSuriben, R. / Chen, M. / Higbee, J. / Oeffinger, J. / Ventura, R. / Li, B. / Mondal, K. / Gao, Z. / Ayupova, D. / Taskar, P. ...Suriben, R. / Chen, M. / Higbee, J. / Oeffinger, J. / Ventura, R. / Li, B. / Mondal, K. / Gao, Z. / Ayupova, D. / Taskar, P. / Li, D. / Starck, S.R. / Chen, H.H. / McEntee, M. / Katewa, S.D. / Phung, V. / Wang, M. / Kekatpure, A. / Lakshminarasimhan, D. / White, A. / Olland, A. / Haldankar, R. / Solloway, M.J. / Hsu, J.Y. / Wang, Y. / Tang, J. / Lindhout, D.A. / Allan, B.B.
External linksNat Med / PubMed:32661391
MethodsX-ray diffraction
Resolution2.91 Å
Structure data

PDB-6wmw:
GFRAL receptor bound with two antibody Fabs (3P10, 25M22)
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / RECEPTOR / SIGNALING / ANTIBODES

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