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TitleThe first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 12635-12647, Year 2020
Publish dateFeb 11, 2020 (structure data deposition date)
AuthorsRavala, S.K. / Hopkins, J.B. / Plescia, C.B. / Allgood, S.R. / Kane, M.A. / Cash, J.N. / Stahelin, R.V. / Tesmer, J.J.G.
External linksJ. Biol. Chem. / PubMed:32661198
MethodsX-ray diffraction
Resolution3.12 Å
Structure data

PDB-6vsk:
Crystal structure of the P-Rex1 DEP1 domain
Method: X-RAY DIFFRACTION / Resolution: 3.12 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / DEP domain / P-Rex1 / metastasis / domain-swapped

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