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TitleMacrocyclic Peptide-Mediated Blockade of the CD47-SIRP alpha Interaction as a Potential Cancer Immunotherapy.
Journal, issue, pagesCell Chem Biol, Vol. 27, Page 1181-1191.e7, Year 2020
Publish dateFeb 14, 2020 (structure data deposition date)
AuthorsHazama, D. / Yin, Y. / Murata, Y. / Matsuda, M. / Okamoto, T. / Tanaka, D. / Terasaka, N. / Zhao, J. / Sakamoto, M. / Kakuchi, Y. ...Hazama, D. / Yin, Y. / Murata, Y. / Matsuda, M. / Okamoto, T. / Tanaka, D. / Terasaka, N. / Zhao, J. / Sakamoto, M. / Kakuchi, Y. / Saito, Y. / Kotani, T. / Nishimura, Y. / Nakagawa, A. / Suga, H. / Matozaki, T.
External linksCell Chem Biol / PubMed:32640189
MethodsX-ray diffraction
Resolution1.36 Å
Structure data

PDB-6lyc:
Crystal structure of the NOD SIRPa complex with D4-2
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

Chemicals

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsCELL ADHESION / complex

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