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Structure paper

TitleExtensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 16949-16960, Year 2020
Publish dateSep 6, 2019 (structure data deposition date)
AuthorsChan, D.T.Y. / Jenkinson, L. / Haynes, S.W. / Austin, M. / Diamandakis, A. / Burschowsky, D. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. ...Chan, D.T.Y. / Jenkinson, L. / Haynes, S.W. / Austin, M. / Diamandakis, A. / Burschowsky, D. / Seewooruthun, C. / Addyman, A. / Fiedler, S. / Ryman, S. / Whitehouse, J. / Slater, L.H. / Gowans, E. / Shibata, Y. / Barnard, M. / Wilkinson, R.W. / Vaughan, T.J. / Holt, S.V. / Cerundolo, V. / Carr, M.D. / Groves, M.A.T.
External linksProc. Natl. Acad. Sci. USA / PubMed:32616569
MethodsX-ray diffraction
Resolution1.78 - 3.25 Å
Structure data

PDB-6ss5:
Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-6ss6:
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / arginase-2 inhibitor / IgG / antigen-binding fragment

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