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TitleThe MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Journal, issue, pagesNat Commun, Vol. 11, Issue 1, Page 3252, Year 2020
Publish dateJun 26, 2020
AuthorsRobert E Turnbull / Louise Fairall / Almutasem Saleh / Emma Kelsall / Kyle L Morris / T J Ragan / Christos G Savva / Aditya Chandru / Christopher J Millard / Olga V Makarova / Corinne J Smith / Alan M Roseman / Andrew M Fry / Shaun M Cowley / John W R Schwabe /
PubMed AbstractMiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle ...MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite implications of involvement in cell cycle regulation and in several cancers, surprisingly little is known about the function or structure of MiDAC. Here we show that MiDAC is important for chromosome alignment during mitosis in cancer cell lines. Mice lacking the MiDAC proteins, DNTTIP1 or MIDEAS, die with identical phenotypes during late embryogenesis due to perturbations in gene expression that result in heart malformation and haematopoietic failure. This suggests that MiDAC has an essential and unique function that cannot be compensated by other HDAC complexes. Consistent with this, the cryoEM structure of MiDAC reveals a unique and distinctive mode of assembly. Four copies of HDAC1 are positioned at the periphery with outward-facing active sites suggesting that the complex may target multiple nucleosomes implying a processive deacetylase function.
External linksNat Commun / PubMed:32591534 / PubMed Central
MethodsEM (single particle)
Resolution4.0 - 4.5 Å
Structure data

11041

6z2j

EMDB-11041, PDB-6z2j:
The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Method: EM (single particle) / Resolution: 4.0 Å

11042

6z2k

EMDB-11042, PDB-6z2k:
The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Method: EM (single particle) / Resolution: 4.5 Å

Chemicals

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / HDAC1 MIDEAS ELMSAN1 DNTTIP1 TDIF1 histone deacetylase MiDAC

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