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TitleCharacterization of Inhibition Reveals Distinctive Properties for Human andSaccharomyces cerevisiaeCRM1.
Journal, issue, pagesJ. Med. Chem., Vol. 63, Page 7545-7558, Year 2020
Publish dateJan 10, 2020 (structure data deposition date)
AuthorsShaikhqasem, A. / Dickmanns, A. / Neumann, P. / Ficner, R.
External linksJ. Med. Chem. / PubMed:32585100
MethodsX-ray diffraction
Resolution3.201 Å
Structure data

PDB-6tvo:
Human CRM1-RanGTP in complex with Leptomycin B
Method: X-RAY DIFFRACTION / Resolution: 3.201 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-LMB:
Leptomycin B, bound form / antifungal, antibiotic*YM

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN / CRM1 / inhibitor / complex / Exportin 1

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