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Structure paper

TitleCrystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 11656-11668, Year 2020
Publish dateMar 16, 2020 (structure data deposition date)
AuthorsSkerlova, J. / Unterlass, J. / Gottmann, M. / Marttila, P. / Homan, E. / Helleday, T. / Jemth, A.S. / Stenmark, P.
External linksJ. Biol. Chem. / PubMed:32571877
MethodsX-ray diffraction
Resolution2.36 - 2.406 Å
Structure data

PDB-6yb8:
Human octameric PAICS in complex with CAIR and SAICAR
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

PDB-6yb9:
Human octameric PAICS in complex with SAICAR, AMP-PNP, and magnesium
Method: X-RAY DIFFRACTION / Resolution: 2.406 Å

Chemicals

ChemComp-C2R:
5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID

ChemComp-OK8:
(2~{S})-2-[[5-azanyl-1-[(2~{R},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]imidazol-4-yl]car

ChemComp-IMD:
IMIDAZOLE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsBIOSYNTHETIC PROTEIN / de novo purine biosynthesis / nucleotide metabolism / cancer target

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