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TitleStructural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology.
Journal, issue, pagesViruses, Vol. 12, Issue 6, Year 2020
Publish dateJun 17, 2020
AuthorsMario Mietzsch / Robert McKenna / Elina Väisänen / Jennifer C Yu / Maria Ilyas / Joshua A Hull / Justin Kurian / J Kennon Smith / Paul Chipman / Yi Lasanajak / David Smith / Maria Söderlund-Venermo / Mavis Agbandje-McKenna /
PubMed AbstractSeveral members of the genus, capable of infecting humans, have been recently discovered, including cutavirus (CuV) and tusavirus (TuV). To begin the characterization of these viruses, we have used ...Several members of the genus, capable of infecting humans, have been recently discovered, including cutavirus (CuV) and tusavirus (TuV). To begin the characterization of these viruses, we have used cryo-electron microscopy and image reconstruction to determine their capsid structures to ~2.9 Å resolution, and glycan array and cell-based assays to identify glycans utilized for cellular entry. Structural comparisons show that the CuV and TuV capsids share common features with other parvoviruses, including an eight-stranded anti-parallel β-barrel, depressions at the icosahedral 2-fold and surrounding the 5-fold axes, and a channel at the 5-fold axes. However, the viruses exhibit significant topological differences in their viral protein surface loops. These result in three separated 3-fold protrusions, similar to the bufaviruses also infecting humans, suggesting a host-driven structure evolution. The surface loops contain residues involved in receptor binding, cellular trafficking, and antigenic reactivity in other parvoviruses. In addition, terminal sialic acid was identified as the glycan potentially utilized by both CuV and TuV for cellular entry, with TuV showing additional recognition of poly-sialic acid and sialylated Lewis X (sLeXLeXLeX) motifs reported to be upregulated in neurotropic and cancer cells, respectively. These structures provide a platform for annotating the cellular interactions of these human pathogens.
External linksViruses / PubMed:32560452 / PubMed Central
MethodsEM (single particle)
Resolution2.87 - 2.88 Å
Structure data

22008

6x2i

EMDB-22008, PDB-6x2i:
The Cutavirus (CuV) capsid structure
Method: EM (single particle) / Resolution: 2.87 Å

22010

6x2k

EMDB-22010, PDB-6x2k:
The Tusavirus (TuV) capsid structure
Method: EM (single particle) / Resolution: 2.88 Å

Source
  • cutavirus
  • tusavirus 1
KeywordsVIRUS / Icosahedral Capsid / Cutavirus / CuV / Protoparvovirus / Tusavirus / TuV

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