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Structure paper

TitleFactor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.
Journal, issue, pagesBlood, Vol. 136, Page 1685-1697, Year 2020
Publish dateOct 2, 2019 (structure data deposition date)
AuthorsKaira, B.G. / Slater, A. / McCrae, K.R. / Dreveny, I. / Sumya, U. / Mutch, N.J. / Searle, M. / Emsley, J.
External linksBlood / PubMed:32559765
MethodsX-ray diffraction
Resolution3.14 - 3.4 Å
Structure data

PDB-6szw:
Asymmetric complex of Factor XII and kininogen with gC1qR/C1QBP/P32 is governed by allostery
Method: X-RAY DIFFRACTION / Resolution: 3.14 Å

PDB-8os5:
Crystal structure of the Factor XII heavy chain reveals an interlocking dimer with a FnII to kringle domain interaction
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / Contact activation / Factor XII heavy chain Crystal structure Thrombosis kringle domain

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