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TitleA conformation-specific ON-switch for controlling CAR T cells with an orally available drug.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 14926-14935, Year 2020
Publish dateDec 20, 2018 (structure data deposition date)
AuthorsZajc, C.U. / Dobersberger, M. / Schaffner, I. / Mlynek, G. / Puhringer, D. / Salzer, B. / Djinovic-Carugo, K. / Steinberger, P. / De Sousa Linhares, A. / Yang, N.J. ...Zajc, C.U. / Dobersberger, M. / Schaffner, I. / Mlynek, G. / Puhringer, D. / Salzer, B. / Djinovic-Carugo, K. / Steinberger, P. / De Sousa Linhares, A. / Yang, N.J. / Obinger, C. / Holter, W. / Traxlmayr, M.W. / Lehner, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:32554495
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-6qba:
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-2T1:
2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid

ChemComp-IMD:
IMIDAZOLE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ZN:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • sulfolobus solfataricus (archaea)
KeywordsTRANSPORT PROTEIN / Lipocalin / RBP4 / Retinol binding protein

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