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TitleAP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.
Journal, issue, pagesNucleic Acids Res., Vol. 48, Page 7345-7355, Year 2020
Publish dateMar 10, 2020 (structure data deposition date)
AuthorsHoitsma, N.M. / Whitaker, A.M. / Beckwitt, E.C. / Jang, S. / Agarwal, P.K. / Van Houten, B. / Freudenthal, B.D.
External linksNucleic Acids Res. / PubMed:32542366
MethodsX-ray diffraction
Resolution2.2 - 2.77 Å
Structure data

PDB-6w4i:
APE1 Y269A product complex with abasic DNA
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6w4t:
APE1 Y269A phosphorothioate substrate complex with abasic DNA
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsLYASE/DNA / DNA Repair / AP-Endonuclease / DNA Binding / DNA BINDING PROTEIN / LYASE-DNA complex / DNA BINDING PROTEIN-DNA complex

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