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TitleT cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 11486-11494, Year 2020
Publish dateDec 19, 2019 (structure data deposition date)
AuthorsColes, C.H. / McMurran, C. / Lloyd, A. / Hock, M. / Hibbert, L. / Raman, M.C.C. / Hayes, C. / Lupardus, P. / Cole, D.K. / Harper, S.
External linksJ. Biol. Chem. / PubMed:32532817
MethodsX-ray diffraction
Resolution1.35 - 3 Å
Structure data

PDB-6trn:
Crystal structure of HLA A2*01-AVYDGREHTV
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

PDB-6tro:
Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / human leukocyte antigen / MAGE-A4 / peptide presentation / T-cell receptor

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