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-Structure paper
Title | Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 117, Page 14127-14138, Year 2020 |
Publish date | Dec 18, 2019 (structure data deposition date) |
![]() | Tsutakawa, S.E. / Sarker, A.H. / Ng, C. / Arvai, A.S. / Shin, D.S. / Shih, B. / Jiang, S. / Thwin, A.C. / Tsai, M.S. / Willcox, A. ...Tsutakawa, S.E. / Sarker, A.H. / Ng, C. / Arvai, A.S. / Shin, D.S. / Shih, B. / Jiang, S. / Thwin, A.C. / Tsai, M.S. / Willcox, A. / Her, M.Z. / Trego, K.S. / Raetz, A.G. / Rosenberg, D. / Bacolla, A. / Hammel, M. / Griffith, J.D. / Cooper, P.K. / Tainer, J.A. |
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Methods | X-ray diffraction |
Resolution | 1.995 Å |
Structure data | ![]() PDB-6vbh: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | DNA BINDING PROTEIN / METALLOPROTEIN / REPLICATION / DNA DAMAGE / DNA REPAIR / NUCLOETIDE EXCISION REPAIR / XPG / Xeroderma pigmentosum / 5' NUCLEASE / HYDROLASE-DNA complex |