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Structure paper

TitleStructural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen.
Journal, issue, pagesNat Commun, Vol. 11, Page 2908-2908, Year 2020
Publish dateFeb 5, 2020 (structure data deposition date)
AuthorsWu, D. / Gallagher, D.T. / Gowthaman, R. / Pierce, B.G. / Mariuzza, R.A.
External linksNat Commun / PubMed:32518267
MethodsX-ray diffraction
Resolution1.83 - 3 Å
Structure data

PDB-6vqo:
T cell receptor-p53-HLA-A2 complex
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6vr1:
Complex of HLA-A2, a class I MHC, with a p53 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-6vr5:
Complex of HLA-A2, a class I MHC, with a p53 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.38 Å

PDB-6vrm:
T cell receptor-p53-HLA-A2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-6vrn:
T cell receptor-p53-HLA-A2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-6vtc:
p53-specific T cell receptor
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-6vth:
p53-specific T cell receptor
Method: X-RAY DIFFRACTION / Resolution: 2.36 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TCR complex / MHC / HLA / adoptive cell therapy

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