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TitleThe CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Journal, issue, pagesNature, Vol. 585, Page 293-297, Year 2020
Publish dateNov 7, 2019 (structure data deposition date)
AuthorsSlabicki, M. / Kozicka, Z. / Petzold, G. / Li, Y.D. / Manojkumar, M. / Bunker, R.D. / Donovan, K.A. / Sievers, Q.L. / Koeppel, J. / Suchyta, D. ...Slabicki, M. / Kozicka, Z. / Petzold, G. / Li, Y.D. / Manojkumar, M. / Bunker, R.D. / Donovan, K.A. / Sievers, Q.L. / Koeppel, J. / Suchyta, D. / Sperling, A.S. / Fink, E.C. / Gasser, J.A. / Wang, L.R. / Corsello, S.M. / Sellar, R.S. / Jan, M. / Gillingham, D. / Scholl, C. / Frohling, S. / Golub, T.R. / Fischer, E.S. / Thoma, N.H. / Ebert, B.L.
External linksNature / PubMed:32494016
MethodsX-ray diffraction
Resolution3.46 Å
Structure data

PDB-6td3:
Structure of DDB1 bound to CR8-engaged CDK12-cyclinK
Method: X-RAY DIFFRACTION / Resolution: 3.46 Å

Chemicals

ChemComp-RC8:
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol

Source
  • homo sapiens (human)
KeywordsLIGASE / ubiquitin ligase kinase cyclin CDK

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