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TitleDesign of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice.
Journal, issue, pagesProtein Sci., Vol. 29, Page 1774-1783, Year 2020
Publish dateSep 13, 2019 (structure data deposition date)
AuthorsDeuschle, F.C. / Schiefner, A. / Brandt, C. / Skerra, A.
External linksProtein Sci. / PubMed:32463547
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-6sua:
Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / Lipocalin / Lcn2 / Anticalin / lipocalin-based binding protein / CD98hc / 4F2hc / amino acid transport / presentation of CD98 light chain / interaction with integrin beta subunit / single-pass type II membrane protein

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