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TitleBrain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Journal, issue, pagesSci Transl Med, Vol. 12, Year 2020
Publish dateMar 9, 2020 (structure data deposition date)
AuthorsKariolis, M.S. / Wells, R.C. / Getz, J.A. / Kwan, W. / Mahon, C.S. / Tong, R. / Kim, D.J. / Srivastava, A. / Bedard, C. / Henne, K.R. ...Kariolis, M.S. / Wells, R.C. / Getz, J.A. / Kwan, W. / Mahon, C.S. / Tong, R. / Kim, D.J. / Srivastava, A. / Bedard, C. / Henne, K.R. / Giese, T. / Assimon, V.A. / Chen, X. / Zhang, Y. / Solanoy, H. / Jenkins, K. / Sanchez, P.E. / Kane, L. / Miyamoto, T. / Chew, K.S. / Pizzo, M.E. / Liang, N. / Calvert, M.E.K. / DeVos, S.L. / Baskaran, S. / Hall, S. / Sweeney, Z.K. / Thorne, R.G. / Watts, R.J. / Dennis, M.S. / Silverman, A.P. / Zuchero, Y.J.Y.
External linksSci Transl Med / PubMed:32461332
MethodsX-ray diffraction
Resolution3.38 Å
Structure data

PDB-6w3h:
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Method: X-RAY DIFFRACTION / Resolution: 3.38 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN TRANSPORT / Blood-Brain Barrier / Transferrin binding receptor / Antibody transport vehicle

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