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TitleEnzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 13000-13011, Year 2020
Publish dateMay 7, 2019 (structure data deposition date)
AuthorsLu, W.C. / Saha, A. / Yan, W. / Garrison, K. / Lamb, C. / Pandey, R. / Irani, S. / Lodi, A. / Lu, X. / Tiziani, S. ...Lu, W.C. / Saha, A. / Yan, W. / Garrison, K. / Lamb, C. / Pandey, R. / Irani, S. / Lodi, A. / Lu, X. / Tiziani, S. / Zhang, Y.J. / Georgiou, G. / DiGiovanni, J. / Stone, E.
External linksProc. Natl. Acad. Sci. USA / PubMed:32434918
MethodsX-ray diffraction
Resolution2.719 Å
Structure data

PDB-6ovg:
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Method: X-RAY DIFFRACTION / Resolution: 2.719 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / Engineering

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