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Structure paper

TitleThe molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 11636-11647, Year 2020
Publish dateNov 25, 2019 (structure data deposition date)
AuthorsSaunders, P.M. / MacLachlan, B.J. / Pymm, P. / Illing, P.T. / Deng, Y. / Wong, S.C. / Oates, C.V.L. / Purcell, A.W. / Rossjohn, J. / Vivian, J.P. / Brooks, A.G.
External linksProc. Natl. Acad. Sci. USA / PubMed:32404419
MethodsX-ray diffraction
Resolution1.27 - 1.98 Å
Structure data

PDB-6v2o:
HLA-B*57:01 presenting the peptide ASLNLPAVSW
Method: X-RAY DIFFRACTION / Resolution: 1.27 Å

PDB-6v2p:
HLA-B*57:03 presenting the peptide ASLNLPAVSW
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-6v2q:
HLA-B*57:03 presenting the peptide LSSPVTKSF
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6v3j:
KIR3DL1 in complex with HLA-B*57:03 presenting the peptide LSSPVTKSF
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Peptide Antigen / HLA / MHC / Immunity

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