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TitleA single mutation increases heavy chain heterodimer assembly of bispecific antibodies by inducing structural disorder in one homodimer species.
Journal, issue, pagesJ. Biol. Chem., Year 2020
Publish dateMar 21, 2018 (structure data deposition date)
AuthorsStutz, C. / Blein, S.
External linksJ. Biol. Chem. / PubMed:32404368
MethodsX-ray diffraction
Resolution1.88 Å
Structure data

PDB-6g1e:
BEAT Fc with improved heterodimerization (Q3A-D84.4Q)
Method: X-RAY DIFFRACTION / Resolution: 1.88 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / TCR / Bispecific / Heterodimer

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