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TitleDe novo development of proteolytically resistant therapeutic peptides for oral administration.
Journal, issue, pagesNat Biomed Eng, Vol. 4, Page 560-571, Year 2020
Publish dateJan 13, 2020 (structure data deposition date)
AuthorsKong, X.D. / Moriya, J. / Carle, V. / Pojer, F. / Abriata, L.A. / Deyle, K. / Heinis, C.
External linksNat Biomed Eng / PubMed:32393891
MethodsX-ray diffraction
Resolution2.86 - 2.91 Å
Structure data

PDB-6twb:
Crystal Structure of the Catalytic Domain of Coagulation Factor XIa in Complex with Double Bridged Peptide F19
Method: X-RAY DIFFRACTION / Resolution: 2.91 Å

PDB-6twc:
Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Double Bridged Peptide F21
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-NH4:
AMMONIUM ION

ChemComp-HOH:
WATER

ChemComp-ACN:
ACETONE

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsBLOOD CLOTTING / Protease / Coagulation factors / Inhibitor / Double bridged peptide / Phage display

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