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Structure paper

TitleStructure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.
Journal, issue, pagesJ. Struct. Biol., Page 107510-107510, Year 2020
Publish dateMar 17, 2018 (structure data deposition date)
AuthorsLi, L. / Wang, M. / Chen, Y. / Hu, T. / Yang, Y. / Zhang, Y. / Bi, G. / Wang, W. / Liu, E. / Han, J. ...Li, L. / Wang, M. / Chen, Y. / Hu, T. / Yang, Y. / Zhang, Y. / Bi, G. / Wang, W. / Liu, E. / Han, J. / Lu, T. / Su, D.
External linksJ. Struct. Biol. / PubMed:32353513
MethodsX-ray diffraction
Resolution2.147 - 3.196 Å
Structure data

PDB-5zit:
Crystal structure of human Enterovirus D68 RdRp in complex with NADPH
Method: X-RAY DIFFRACTION / Resolution: 3.196 Å

PDB-6l4r:
Crystal structure of Enterovirus D68 RdRp
Method: X-RAY DIFFRACTION / Resolution: 2.147 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • enterovirus d68
KeywordsRNA BINDING PROTEIN / EVD68-RdRp / Complex / Inhibitor / NADPH-Na4 / Structure-based design

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