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-Structure paper
Title | Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with StrongIn VivoAntitumor Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 4997-5010, Year 2020 |
Publish date | Apr 22, 2020 (structure data deposition date) |
![]() | Xu, S. / Aguilar, A. / Huang, L. / Xu, T. / Zheng, K. / McEachern, D. / Przybranowski, S. / Foster, C. / Zawacki, K. / Liu, Z. ...Xu, S. / Aguilar, A. / Huang, L. / Xu, T. / Zheng, K. / McEachern, D. / Przybranowski, S. / Foster, C. / Zawacki, K. / Liu, Z. / Chinnaswamy, K. / Stuckey, J. / Wang, S. |
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Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | ![]() PDB-6wnh: |
Chemicals | ![]() ChemComp-7MM: ![]() ChemComp-7PR: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / Inhibitor / PROTEIN BINDING |