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-Structure paper
Title | Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. |
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Journal, issue, pages | Neuron, Vol. 107, Page 82-94.e6, Year 2020 |
Publish date | Dec 9, 2019 (structure data deposition date) |
Authors | Escande-Beillard, N. / Loh, A. / Saleem, S.N. / Kanata, K. / Hashimoto, Y. / Altunoglu, U. / Metoska, A. / Grandjean, J. / Ng, F.M. / Pomp, O. ...Escande-Beillard, N. / Loh, A. / Saleem, S.N. / Kanata, K. / Hashimoto, Y. / Altunoglu, U. / Metoska, A. / Grandjean, J. / Ng, F.M. / Pomp, O. / Baburajendran, N. / Wong, J. / Hill, J. / Beillard, E. / Cozzone, P. / Zaki, M. / Kayserili, H. / Hamada, H. / Shiratori, H. / Reversade, B. |
External links | Neuron / PubMed:32330411 |
Methods | X-ray diffraction |
Resolution | 3.4 Å |
Structure data | PDB-6lhm: |
Source |
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Keywords | OXIDOREDUCTASE / PYCR2 / carboxylate / P5CR / decamer / pentamer / Pyrroline-5-carboxylate reductase |