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Structure paper

TitleTolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Journal, issue, pagesFebs J., Vol. 288, Page 310-324, Year 2021
Publish dateJan 14, 2020 (structure data deposition date)
AuthorsPinheiro, F. / Varejao, N. / Esperante, S. / Santos, J. / Velazquez-Campoy, A. / Reverter, D. / Pallares, I. / Ventura, S.
External linksFebs J. / PubMed:32324953
MethodsX-ray diffraction
Resolution1.153 - 1.7 Å
Structure data

PDB-6txv:
A25T Transthyretin structure in complex with Tolcalpone
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6txw:
V30G Transthyretin structure in complex with Tolcalpone
Method: X-RAY DIFFRACTION / Resolution: 1.153 Å

PDB-6xtk:
Y114C Transthyretin structure in complex with Tolcalpone
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-TCW:
Tolcapone / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Drug repositioning / tolcapone / leptomeningeal amyloidosis

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