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Structure paper

TitleHigh resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition.
Journal, issue, pagesNucleic Acids Res., Vol. 48, Page 5766-5776, Year 2020
Publish dateNov 25, 2018 (structure data deposition date)
AuthorsOu, A. / Schmidberger, J.W. / Wilson, K.A. / Evans, C.W. / Hargreaves, J.A. / Grigg, M. / O'Mara, M.L. / Iyer, K.S. / Bond, C.S. / Smith, N.M.
External linksNucleic Acids Res. / PubMed:32313953
MethodsX-ray diffraction
Resolution1.6 - 1.801 Å
Structure data

PDB-6n65:
KRAS G-quadruplex G16T mutant.
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6wck:
KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 and T16.
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA / KRAS / G-quadruplex / promoter sequence / G16T mutant / Bromouracil

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