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TitleAllosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-beta-synthase domain.
Journal, issue, pagesNat Commun, Vol. 11, Page 1837-1837, Year 2020
Publish dateFeb 21, 2019 (structure data deposition date)
AuthorsImamura, A. / Okada, T. / Mase, H. / Otani, T. / Kobayashi, T. / Tamura, M. / Kubata, B.K. / Inoue, K. / Rambo, R.P. / Uchiyama, S. ...Imamura, A. / Okada, T. / Mase, H. / Otani, T. / Kobayashi, T. / Tamura, M. / Kubata, B.K. / Inoue, K. / Rambo, R.P. / Uchiyama, S. / Ishii, K. / Nishimura, S. / Inui, T.
External linksNat Commun / PubMed:32296055
MethodsX-ray diffraction
Resolution1.903 - 2.804 Å
Structure data

PDB-6jig:
Crystal structure of GMP reductase C318A from Trypanosoma brucei in complex with guanosine 5'-monophosphate
Method: X-RAY DIFFRACTION / Resolution: 1.903 Å

PDB-6jl8:
Crystal structure of GMP reductase C318A from Trypanosoma brucei
Method: X-RAY DIFFRACTION / Resolution: 2.804 Å

PDB-6lk4:
Crystal structure of GMP reductase from Trypanosoma brucei in complex with guanosine 5'-triphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.503 Å

Chemicals

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

Source
  • trypanosoma brucei brucei (strain iltat1.4) (eukaryote)
  • trypanosoma brucei brucei (eukaryote)
KeywordsOXIDOREDUCTASE / Trypanosoma brucei / 5'-monophosphate reductase / guanosine 5'-monophosphate / cystathionine beta synthase motif / guanosine 5'-triphosphate

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