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-Structure paper
| Title | Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 11, Page 558-565, Year 2020 |
| Publish date | Jan 9, 2020 (structure data deposition date) |
 Authors | Mathison, C.J.N. / Chianelli, D. / Rucker, P.V. / Nelson, J. / Roland, J. / Huang, Z. / Yang, Y. / Jiang, J. / Xie, Y.F. / Epple, R. ...Mathison, C.J.N. / Chianelli, D. / Rucker, P.V. / Nelson, J. / Roland, J. / Huang, Z. / Yang, Y. / Jiang, J. / Xie, Y.F. / Epple, R. / Bursulaya, B. / Lee, C. / Gao, M.Y. / Shaffer, J. / Briones, S. / Sarkisova, Y. / Galkin, A. / Li, L. / Li, N. / Li, C. / Hua, S. / Kasibhatla, S. / Kinyamu-Akunda, J. / Kikkawa, R. / Molteni, V. / Tellew, J.E. |
 External links | Acs Med. Chem. Lett. / PubMed:32292564 |
| Methods | X-ray diffraction |
| Resolution | 2.303 Å |
| Structure data |  PDB-6vhg: |
| Chemicals |  ChemComp-QX1:  ChemComp-SO4:  ChemComp-CL:  ChemComp-ACT:  ChemComp-HOH: |
| Source |
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 Keywords | Transferase/Transferase Inhibitor / Inhibitor / Complex / Tyrosine kinase / catalytic domain / Transferase-Transferase Inhibitor complex |
homo sapiens (human)