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TitleDiscovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 11, Page 506-513, Year 2020
Publish dateJan 31, 2020 (structure data deposition date)
AuthorsBlomgren, P. / Chandrasekhar, J. / Di Paolo, J.A. / Fung, W. / Geng, G. / Ip, C. / Jones, R. / Kropf, J.E. / Lansdon, E.B. / Lee, S. ...Blomgren, P. / Chandrasekhar, J. / Di Paolo, J.A. / Fung, W. / Geng, G. / Ip, C. / Jones, R. / Kropf, J.E. / Lansdon, E.B. / Lee, S. / Lo, J.R. / Mitchell, S.A. / Murray, B. / Pohlmeyer, C. / Schmitt, A. / Suekawa-Pirrone, K. / Wise, S. / Xiong, J.M. / Xu, J. / Yu, H. / Zhao, Z. / Currie, K.S.
External linksAcs Med. Chem. Lett. / PubMed:32292557
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-6vov:
Crystal structure of Syk in complex with GS-9876
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-R6D:
6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Spleen tyrosine kinase B-cell Syk

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