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TitleMolecular mechanism of the dual regulatory roles of ATP on the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase.
Journal, issue, pagesSci Rep, Vol. 10, Page 6225-6225, Year 2020
Publish dateOct 22, 2019 (structure data deposition date)
AuthorsSun, P. / Bai, T. / Ma, T. / Ding, J.
External linksSci Rep / PubMed:32277159
MethodsX-ray diffraction
Resolution2.254 - 2.302 Å
Structure data

PDB-6l57:
Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT , Mg and ATP binding at allosteric site.
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

PDB-6l59:
Crystal structure of the alpha gamma heterodimer of human IDH3 in complex with CIT, Mg and ATP binding at allosteric site and Mg, ATP binding at active site.
Method: X-RAY DIFFRACTION / Resolution: 2.254 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CIT:
CITRIC ACID

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / TCA cycle / NAD-Isocitrate Dehydrogenase

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