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TitleLats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.
Journal, issue, pagesCell Stem Cell, Vol. 26, Page 675-692.e8, Year 2020
Publish dateFeb 9, 2018 (structure data deposition date)
AuthorsLi, Q. / Sun, Y. / Jarugumilli, G.K. / Liu, S. / Dang, K. / Cotton, J.L. / Xiol, J. / Chan, P.Y. / DeRan, M. / Ma, L. ...Li, Q. / Sun, Y. / Jarugumilli, G.K. / Liu, S. / Dang, K. / Cotton, J.L. / Xiol, J. / Chan, P.Y. / DeRan, M. / Ma, L. / Li, R. / Zhu, L.J. / Li, J.H. / Leiter, A.B. / Ip, Y.T. / Camargo, F.D. / Luo, X. / Johnson, R.L. / Wu, X. / Mao, J.
External linksCell Stem Cell / PubMed:32259481
MethodsX-ray diffraction
Resolution2.32 Å
Structure data

PDB-6cdy:
Crystal structure of TEAD complexed with its inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-EY1:
2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
Keywordstranscription/transcription inhibitor / Transcription factor / transcription-transcription inhibitor complex

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