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Structure paper

TitleCrystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 27, Page 319-322, Year 2020
Publish dateOct 9, 2019 (structure data deposition date)
AuthorsMatyskiela, M.E. / Clayton, T. / Zheng, X. / Mayne, C. / Tran, E. / Carpenter, A. / Pagarigan, B. / McDonald, J. / Rolfe, M. / Hamann, L.G. ...Matyskiela, M.E. / Clayton, T. / Zheng, X. / Mayne, C. / Tran, E. / Carpenter, A. / Pagarigan, B. / McDonald, J. / Rolfe, M. / Hamann, L.G. / Lu, G. / Chamberlain, P.P.
External linksNat. Struct. Mol. Biol. / PubMed:32251415
MethodsX-ray diffraction
Resolution3.58 Å
Structure data

PDB-6uml:
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Method: X-RAY DIFFRACTION / Resolution: 3.58 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-Y70:
S-Pomalidomide

Source
  • homo sapiens (human)
KeywordsLIGASE / CELMoD / cereblon-CRL4 / ubiquitin ligase / C2H2 zinc finger

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