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Structure paper

TitleMolecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Journal, issue, pagesCommun Biol, Vol. 3, Page 163-163, Year 2020
Publish dateJun 27, 2019 (structure data deposition date)
AuthorsOikawa, D. / Sato, Y. / Ohtake, F. / Komakura, K. / Hanada, K. / Sugawara, K. / Terawaki, S. / Mizukami, Y. / Phuong, H.T. / Iio, K. ...Oikawa, D. / Sato, Y. / Ohtake, F. / Komakura, K. / Hanada, K. / Sugawara, K. / Terawaki, S. / Mizukami, Y. / Phuong, H.T. / Iio, K. / Obika, S. / Fukushi, M. / Irie, T. / Tsuruta, D. / Sakamoto, S. / Tanaka, K. / Saeki, Y. / Fukai, S. / Tokunaga, F.
External linksCommun Biol / PubMed:32246052
MethodsX-ray diffraction
Resolution1.543 - 2.123 Å
Structure data

PDB-6kc5:
HOIP-HOIPIN1 complex
Method: X-RAY DIFFRACTION / Resolution: 1.543 Å

PDB-6kc6:
HOIP-HOIPIN8 complex
Method: X-RAY DIFFRACTION / Resolution: 2.123 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-D5U:
2-[3-(2-methoxyphenyl)-3-oxidanylidene-propyl]benzoic acid

ChemComp-GOL:
GLYCEROL

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-D60:
2-[3-[2,6-bis(fluoranyl)-4-(1~{H}-pyrazol-4-yl)phenyl]-3-oxidanylidene-propyl]-4-(1-methylpyrazol-4-yl)benzoic acid

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / UBIQUITIN / E3 / INHIBITOR COMPLEX

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