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Structure paper

TitleX-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains.
Journal, issue, pagesProtein Sci., Vol. 29, Page 1679-1686, Year 2020
Publish dateAug 30, 2019 (structure data deposition date)
AuthorsLarson, E.T. / Brennan, D.L. / Hickey, E.R. / Ganesan, R. / Kroe-Barrett, R. / Farrow, N.A.
External linksProtein Sci. / PubMed:32239732
MethodsX-ray diffraction
Resolution2.31 Å
Structure data

PDB-6u6u:
IL36R extracellular domain in complex with BI655130 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / IL36R

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