タイトル | The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II. |
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ジャーナル・号・ページ | Biomolecules, Vol. 10, Year 2020 |
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掲載日 | 2019年4月18日 (構造データの登録日) |
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著者 | Glockner, S. / Ngo, K. / Wagner, B. / Heine, A. / Klebe, G. |
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リンク | Biomolecules / PubMed:32230853 |
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手法 | X線回折 |
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解像度 | 0.929 - 1.14 Å |
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構造データ | PDB-6rh4: Human Carbonic Anhydrase II in complex with 4-Nitrobenzenesulfonamide. 手法: X-RAY DIFFRACTION / 解像度: 0.948 Å PDB-6rit: Human Carbonic Anhydrase II in complex with 2-Fluorobenzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.007 Å PDB-6rjj: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.056 Å PDB-6rkn: Human Carbonic Anhydrase II in complex with a fluorinated Benzenesulfonamide. 手法: X-RAY DIFFRACTION / 解像度: 0.959 Å PDB-6rl9: Human Carbonic Anhydrase II in complex with 4-Aminobenzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1 Å PDB-6rnp: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.07 Å PDB-6rob: Human Carbonic Anhydrase II in complex with 4-cyanobenzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 0.929 Å PDB-6roe: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 0.939 Å PDB-6rqi: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-6rrg: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.127 Å PDB-6rri: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.097 Å PDB-6rs5: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.07 Å PDB-6rsz: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.089 Å PDB-6s9g: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.14 Å PDB-6sd7: Human Carbonic Anhydrase II in complex with fluorinated benzenesulfonamide and its dimer 手法: X-RAY DIFFRACTION / 解像度: 1.05 Å |
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化合物 | ChemComp-KGK: 2,3,5,6-tetrakis(fluoranyl)-4-methyl-benzenesulfonamide
ChemComp-KJ5: 4-ethyl-2,3,5,6-tetrakis(fluoranyl)benzenesulfonamide
ChemComp-L1Q: 2,3,5,6-tetrakis(fluoranyl)-4-propyl-benzenesulfonamide
ChemComp-SXG: 2,3,4,5,6-pentafluoro-N-(2,3,5,6-tetrafluoro-4-sulfamoylphenyl)benzenesulfonamide
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由来 | homo sapiens (ヒト)
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キーワード | LYASE / Inihibitor / complex / CO2 conversion / Inhibitor |
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