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Structure paper

TitleCrystal Structure of Keratin 1/10(C401A) 2B Heterodimer Demonstrates a Proclivity for the C-Terminus of Helix 2B to Form Higher Order Molecular Contacts.
Journal, issue, pagesYale J Biol Med, Vol. 93, Page 3-17, Year 2020
Publish dateOct 30, 2019 (structure data deposition date)
AuthorsLomakin, I.B. / Hinbest, A.J. / Ho, M. / Eldirany, S.A. / Bunick, C.G.
External linksPubMed:32226330
MethodsX-ray diffraction
Resolution2.069 Å
Structure data

PDB-6uui:
Crystal structure of the heterocomplex between coil 2B domains of wild-type keratin 1 (KRT1) and keratin 10 (KRT10) containing mutation Cys401Ala
Method: X-RAY DIFFRACTION / Resolution: 2.069 Å

Chemicals

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN FIBRIL / intermediate filament / cytoskeleton / skin / coiled-coil

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