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Structure paper

TitleAntigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding.
Journal, issue, pagesStructure, Year 2020
Publish dateFeb 22, 2018 (structure data deposition date)
AuthorsOrlandi, C. / Deredge, D. / Ray, K. / Gohain, N. / Tolbert, W. / DeVico, A.L. / Wintrode, P. / Pazgier, M. / Lewis, G.K.
External linksStructure / PubMed:32209433
MethodsX-ray diffraction
Resolution2.4 - 2.575 Å
Structure data

PDB-6chf:
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 1)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6cjc:
CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3)
Method: X-RAY DIFFRACTION / Resolution: 2.575 Å

PDB-6cjx:
Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 2)
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin / IgG1 / immunoglobulin-like beta sandwich / FC fragment / LALA mutation

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