+Search query
-Structure paper
Title | The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI. |
---|---|
Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 59, Page 10549-10556, Year 2020 |
Publish date | Nov 1, 2019 (structure data deposition date) |
Authors | Fage, C.D. / Lathouwers, T. / Vanmeert, M. / Gao, L.J. / Vrancken, K. / Lammens, E.M. / Weir, A.N.M. / Degroote, R. / Cuppens, H. / Kosol, S. ...Fage, C.D. / Lathouwers, T. / Vanmeert, M. / Gao, L.J. / Vrancken, K. / Lammens, E.M. / Weir, A.N.M. / Degroote, R. / Cuppens, H. / Kosol, S. / Simpson, T.J. / Crump, M.P. / Willis, C.L. / Herdewijn, P. / Lescrinier, E. / Lavigne, R. / Anne, J. / Masschelein, J. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:32208550 |
Methods | X-ray diffraction |
Resolution | 2.45 - 2.55 Å |
Structure data | PDB-6tbb: PDB-6tbc: |
Chemicals | ChemComp-NDP: ChemComp-KAL: ChemComp-HOH: ChemComp-N5H: |
Source |
|
Keywords | BIOSYNTHETIC PROTEIN / enoyl-[acyl carrier protein] reductase / fatty acid biosynthesis / Rossmann fold / short-chain dehydrogenase/reductase |