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Structure paper

TitleRetinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.
Journal, issue, pagesSci Adv, Vol. 6, Page eaay8937-eaay8937, Year 2020
Publish dateDec 6, 2017 (structure data deposition date)
AuthorsLee, S.A. / Yang, K.J.Z. / Brun, P.J. / Silvaroli, J.A. / Yuen, J.J. / Shmarakov, I. / Jiang, H. / Feranil, J.B. / Li, X. / Lackey, A.I. ...Lee, S.A. / Yang, K.J.Z. / Brun, P.J. / Silvaroli, J.A. / Yuen, J.J. / Shmarakov, I. / Jiang, H. / Feranil, J.B. / Li, X. / Lackey, A.I. / Krezel, W. / Leibel, R.L. / Libien, J. / Storch, J. / Golczak, M. / Blaner, W.S.
External linksSci Adv / PubMed:32195347
MethodsX-ray diffraction
Resolution1.35 - 1.45 Å
Structure data

PDB-6bth:
Crystal structure of human cellular retinol binding protein 2 (CRBP2) in complex with 2-arachidonoylglycerol (2-AG)
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

PDB-6bti:
Crystal structure of human cellular retinol binding protein 2 (CRBP2) in complex with N-arachidonoylethanolamine (AEA)
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

Chemicals

ChemComp-ECB:
1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate / agonist*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-E7Y:
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide / neurotransmitter*YM

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / endocannabinoid / 2-arachidonoylglycerol / 2-AG / retinol / vitamin A / N-arachidonoylethanolamine / anandamide

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