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TitleMechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 6187-6201, Year 2020
Publish dateJun 1, 2019 (structure data deposition date)
AuthorsZhang, R.Y. / Yu, Z.H. / Chen, L. / Walls, C.D. / Zhang, S. / Wu, L. / Zhang, Z.Y.
External linksJ. Biol. Chem. / PubMed:32188694
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-5bk8:
Cancer-associated SHP2/T507K mutant
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Phosphatase / SHP2 / PTPN11 / T507K

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