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TitleCharacterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
Journal, issue, pagesPlos Biol., Vol. 18, Page e3000618-e3000618, Year 2020
Publish dateFeb 12, 2019 (structure data deposition date)
AuthorsYin, L. / Masuyer, G. / Zhang, S. / Zhang, J. / Miyashita, S.I. / Burgin, D. / Lovelock, L. / Coker, S.F. / Fu, T.M. / Stenmark, P. / Dong, M.
External linksPlos Biol. / PubMed:32182233
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6qns:
Crystal structure of the binding domain of Botulinum Neurotoxin type B mutant I1248W/V1249W in complex with human synaptotagmin 1 and GD1a receptors
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • clostridium botulinum (bacteria)
  • homo sapiens (human)
KeywordsTOXIN / botulinum toxin

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