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TitleHIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.
Journal, issue, pagesNat. Chem. Biol., Vol. 16, Page 529-537, Year 2020
Publish dateNov 30, 2019 (structure data deposition date)
AuthorsXiao, T. / Frey, G. / Fu, Q. / Lavine, C.L. / Scott, D.A. / Seaman, M.S. / Chou, J.J. / Chen, B.
External linksNat. Chem. Biol. / PubMed:32152540
MethodsNMR (solution)
Structure data

PDB-6v4t:
MPER-TMD of HIV-1 Env bound with the entry inhibitor S2C3
Method: SOLUTION NMR

Chemicals

ChemComp-QOJ:
4-[10-(9-azanyl-2,3-dihydro-1~{H}-cyclopenta[b]quinolin-4-yl)decyl]-2,3-dihydro-1~{H}-cyclopenta[b]quinolin-9-amine

Source
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN / HIV-1 Env / small-molecule / entry inhibitor / MPER

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