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TitleFatal amyloid formation in a patient's antibody light chain is caused by a single point mutation.
Journal, issue, pagesElife, Vol. 9, Year 2020
Publish dateAug 21, 2019 (structure data deposition date)
AuthorsKazman, P. / Vielberg, M.T. / Pulido Cendales, M.D. / Hunziger, L. / Weber, B. / Hegenbart, U. / Zacharias, M. / Kohler, R. / Schonland, S. / Groll, M. / Buchner, J.
External linksElife / PubMed:32151314
MethodsX-ray diffraction
Resolution1.55 - 2.5 Å
Structure data

PDB-6sm1:
Wild type immunoglobulin light chain (WT-1)
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-6sm2:
Mutant immunoglobulin light chain causing amyloidosis (Pat-1)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / AL Amyloidosis / Antibody Folding / Protein Stability / Dynamics / PROTEIN FIBRIL

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