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Structure paper

TitleDiscovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 142, Page 4960-4964, Year 2020
Publish dateAug 13, 2019 (structure data deposition date)
AuthorsWan, X. / Yang, T. / Cuesta, A. / Pang, X. / Balius, T.E. / Irwin, J.J. / Shoichet, B.K. / Taunton, J.
External linksJ. Am. Chem. Soc. / PubMed:32105459
MethodsX-ray diffraction
Resolution1.79 - 1.96 Å
Structure data

PDB-6u06:
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-6u09:
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

Chemicals

ChemComp-EI8:
3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride

ChemComp-HOH:
WATER

ChemComp-EI9:
3-{(1-oxo-1,2-dihydroisoquinolin-7-yl)[(pyridin-4-yl)methyl]sulfamoyl}benzene-1-sulfonyl fluoride

Source
  • mus musculus (house mouse)
KeywordsTRANSLATION / cap-binding site / anti-neoplastic / inhibitor / translation initiation blocking / TRANSLATION-INHIBITOR complex / TRANSLATION/INHIBITOR

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