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TitleStructural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 5404-5418, Year 2020
Publish dateOct 10, 2019 (structure data deposition date)
AuthorsDagbay, K.B. / Treece, E. / Streich Jr., F.C. / Jackson, J.W. / Faucette, R.R. / Nikiforov, A. / Lin, S.C. / Boston, C.J. / Nicholls, S.B. / Capili, A.D. / Carven, G.J.
External linksJ. Biol. Chem. / PubMed:32075906
MethodsX-ray diffraction
Resolution2.79 Å
Structure data

PDB-6umx:
Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/IMMUNE SYSTEM / Myostatin / GDF8 / transforming growth factor beta / muscle wasting disease / antibody / fab / SIGNALING PROTEIN-IMMUNE SYSTEM complex

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